


The MRWC-based method was also applied to the MR imaging data of a virtual head phantom obtained from a three-dimensional MRI simulated brain database. Thereafter, the method was evaluated in terms of the mass-fraction quantification accuracy by comparing it with the gold-standard CT-based method developed by Schneider et al.

: A numerical analysis of the MRWC-based method was performed for 47 standard human soft tissues tabulated in the literature as objects of interest with unknown mass fractions of the four main elements-C, O, H, and N. This method relies on an empirical one-to-one correspondence between the mass fraction and water content (WC), which is a measurable tissue quantity based on magnetic resonance (MR) imaging (referred to as “MRWC-based method”). : A method for quantitatively predicting carbon and oxygen concentrations in human soft tissues is proposed. : In-situ range verification of particle therapy based on the detection of secondary emitted radiation requires highly accurate assignment of elemental concentrations (particularly carbon and oxygen) in the human body.
